PPIRE01857
Target Protein Information
| Protein_Name | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
|---|---|
| Protein_Sequence | MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE |
| Organism_Source | Homo sapiens |
| Functional_Classification | Enzyme |
| Cellular_Localization | Nucleus |
| Gene_Names | PIN1 |
| UniProt_ID | Q13526 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | CTD-S2/S5 |
|---|---|
| Peptide_Sequence | YpSPTpSPS |
| Peptide_Length | 9 |
| Peptide_SMILES | C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O |
| Chemical_Modification | p2=O-phosphoserine; p5=O-phosphoserine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 932.00 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.11111 |
| Average_Rotatable_Bonds | 2.11111 |
| Charge_at_pH_7 | -0.00287 |
| Isoelectric_Point | 6.09320 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 15 |
| Number_of_Hydrogen_Bond_Donors | 11 |
| Topological_Polar_Surface_Area | 362.11000 |
| X_logP_energy | -5.39250 |
Interaction Information
| Affinity | KD=4.9 uM |
|---|---|
| Affinity_Assay | Bio-Layer Interferometry |
| PDB_ID | 1F8A |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | STRUCTURAL BASIS FOR THE PHOSPHOSERINE-PROLINE RECOGNITION BY GROUP IV WW DOMAINS |
| Release_Year | 2000 |
| PMID | None |
| DOI | 10.2210/pdb1f8a/pdb |