PPIRE01909

Target Protein Information
Protein_Name Interleukin-7 receptor subunit alpha
Protein_Sequence MTILGTTFGMVFSLLQVVSGESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFEDPDVNITNLEFEICGALVEVKCLNFRKLQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIVKPEAPFDLSVVYREGANDFVVTFNTSHLQKKYVKVLMHDVAYRQEKDENKWTHVNLSSTKLTLLQRKLQPAAMYEIKVRSIPDHYFKGFWSEWSPSYYFRTPEINNSSGEMDPILLTISILSFFSVALLVILACVLWKKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ
Organism_Source Homo sapiens
Functional_Classification receptor
Cellular_Localization Plasma membrane
Gene_Names IL7R
UniProt_ID P16871
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P725
Peptide_Sequence CKIMKSMPC
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method C1<->C8, side chain cyclization, disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1040.38
Aliphatic_Index 43.33333
Aromaticity 0.00000
Average_Rotatable_Bonds 3.88889
Charge_at_pH_7 1.87344
Isoelectric_Point 8.82168
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 359.60000
X_logP_energy -2.55490
Interaction Information
Affinity KD=1.1 uM
Affinity_Assay ELISA
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Screening for peptides targeted to IL-7RAlpha for molecular imaging of rheumatoid arthritis synovium.
Release_Year 2016
PMID 27729062
DOI 10.1186/s13075-016-1133-8