PPIRE01982

Target Protein Information
Protein_Name Substance-P receptor
Protein_Sequence MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
Organism_Source Rattus norvegicus
Functional_Classification receptor
Cellular_Localization Plasma membrane
Gene_Names Tacr1
UniProt_ID P14600
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Substance P
Peptide_Sequence RPKPQQFFGLM
Peptide_Length 11
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1348.63
Aliphatic_Index 35.45455
Aromaticity 0.18182
Average_Rotatable_Bonds 3.81818
Charge_at_pH_7 1.99769
Isoelectric_Point 11.65178
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 510.84000
X_logP_energy -2.90203
Interaction Information
Affinity KD=45.3 pM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title 125I-substance P binding sites in rat spinal cord in a chronic constriction injury and following dorsal rhizotomy.
Release_Year 1991
PMID 1719878
DOI 10.1111/j.1749-6632.1991.tb33122.x