PPIRE02083

Target Protein Information
Protein_Name GRB2-related adapter protein 2
Protein_Sequence MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDINDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMTR
Organism_Source Homo sapiens
Functional_Classification E3 ubiquitin ligase adaptors
Cellular_Localization Cytoplasm
Gene_Names GRAP2
UniProt_ID O75791
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Gab1(2)aa515-527
Peptide_Sequence RNLKPDRKVKPAP
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1518.83
Aliphatic_Index 60.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.76923
Charge_at_pH_7 3.99754
Isoelectric_Point 11.75115
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 668.40000
X_logP_energy -6.27986
Interaction Information
Affinity KD=11.179 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 1OEB
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes.
Release_Year 2003
PMID 12773381
DOI 10.1093/emboj/cdg257