PPIRE02084

Target Protein Information
Protein_Name GRB2-related adapter protein 2
Protein_Sequence MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDINDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMTR
Organism_Source Homo sapiens
Functional_Classification E3 ubiquitin ligase adaptors
Cellular_Localization Cytoplasm
Gene_Names GRAP2
UniProt_ID O75791
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Gab1(3)aa521-533
Peptide_Sequence SNTPPPRPPKPSH
Peptide_Length 13
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1411.58
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.61538
Charge_at_pH_7 2.08860
Isoelectric_Point 11.65179
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 580.16000
X_logP_energy -8.14803
Interaction Information
Affinity KD=0.387 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 1OEB
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes.
Release_Year 2003
PMID 12773381
DOI 10.1093/emboj/cdg257