PPIRE02100
Target Protein Information
| Protein_Name | Baculoviral IAP repeat-containing protein 5 |
|---|---|
| Protein_Sequence | MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD |
| Organism_Source | Homo sapiens |
| Functional_Classification | other |
| Cellular_Localization | Nucleus |
| Gene_Names | BIRC5 |
| UniProt_ID | O15392 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | H3(1-4) |
|---|---|
| Peptide_Sequence | ARTK |
| Peptide_Length | 4 |
| Peptide_SMILES | C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 474.56 |
|---|---|
| Aliphatic_Index | 25.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.00000 |
| Charge_at_pH_7 | 1.99769 |
| Isoelectric_Point | 11.65178 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 8 |
| Number_of_Hydrogen_Bond_Donors | 10 |
| Topological_Polar_Surface_Area | 258.77000 |
| X_logP_energy | -3.35433 |
Interaction Information
| Affinity | KD=60.6 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. |
| Release_Year | 2012 |
| PMID | 22357620 |
| DOI | 10.1091/mbc.E11-11-0904 |