PPIRE02107

Target Protein Information
Protein_Name Melanocyte-stimulating hormone receptor
Protein_Sequence MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
Organism_Source Mus musculus
Functional_Classification receptor
Cellular_Localization Plasma membrane
Gene_Names Mc1r
UniProt_ID Q01727
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ALB-G3
Peptide_Sequence KGGGXDHfRWK
Peptide_Length 11
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification X5=Norleucine; K1=4-p-(tolyl)butyric acid
Cyclization_Method D6<->K11; side chain cyclization; amide bond
Linear/Cyclic Cyclic
N-terminal_Modification Other
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1244.38
Aliphatic_Index 0.00000
Aromaticity 0.18182
Average_Rotatable_Bonds 3.72727
Charge_at_pH_7 2.08875
Isoelectric_Point 10.78905
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 550.03000
X_logP_energy -5.29963
Interaction Information
Affinity IC50=0.51 nM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title The Effect of Albumin-Binding Moiety on Tumor Targeting and Biodistribution Properties of 67Ga-Labeled Albumin Binder-Conjugated Alpha-Melanocyte-Stimulating Hormone Peptides.
Release_Year 2022
PMID 34762521
DOI 10.1089/cbr.2021.0273