PPIRE02122

Target Protein Information
Protein_Name Troponin C, slow skeletal and cardiac muscles
Protein_Sequence MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE
Organism_Source Homo sapiens
Functional_Classification E3 ubiquitin ligase adaptors
Cellular_Localization Cytoplasm
Gene_Names TNNC1
UniProt_ID P63316
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name cIp-s
Peptide_Sequence TQKIFDLRGKFKRPTLRRVR
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2516.04
Aliphatic_Index 73.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 4.40000
Charge_at_pH_7 6.99753
Isoelectric_Point 12.68998
Number_of_Hydrogen_Bond_Acceptors 33
Number_of_Hydrogen_Bond_Donors 42
Topological_Polar_Surface_Area 1115.84000
X_logP_energy -9.76805
Interaction Information
Affinity KD=31 uM
Affinity_Assay NMR chemical shift perturbation
PDB_ID 1OZS
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I.
Release_Year 2003
PMID 12732641
DOI 10.1074/jbc.M302497200