PPIRE02175

Target Protein Information
Protein_Name H-2 class I histocompatibility antigen, L-D alpha chain
Protein_Sequence MGAMAPRTLLLLLAAALAPTQTRAGPHSMRYFETAVSRPGLGEPRYISVGYVDNKEFVRFDSDAENPRYEPQAPWMEQEGPEYWERITQIAKGQEQWFRVNLRTLLGYYNQSAGGTHTLQWMYGCDVGSDGRLLRGYEQFAYDGCDYIALNEDLKTWTAADMAAQITRRKWEQAGAAEYYRAYLEGECVEWLHRYLKNGNATLLRTDSPKAHVTHHPRSKGEVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVYHEGLPEPLTLRWEPPPSTDSYMVIVAVLGVLGAMAIIGAVVAFVMKRRRNTGGKGGDYALAPGSQSSEMSLRDCKA
Organism_Source Mus musculus
Functional_Classification Immune-related protein
Cellular_Localization Plasma membrane
Gene_Names H2-L
UniProt_ID P01897
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name QL9
Peptide_Sequence QLSPFPFDL
Peptide_Length 9
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1063.22
Aliphatic_Index 86.66667
Aromaticity 0.22222
Average_Rotatable_Bonds 3.22222
Charge_at_pH_7 -1.00157
Isoelectric_Point 3.74999
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 379.16000
X_logP_energy -1.40080
Interaction Information
Affinity Ki=0.06667 uM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.
Release_Year 1994
PMID 7972089
DOI 10.1073/pnas.91.24.11487