PPIRE02326

Target Protein Information
Protein_Name Polyubiquitin-B
Protein_Sequence MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGC
Organism_Source Homo sapiens
Functional_Classification other
Cellular_Localization Cytoplasm
Gene_Names UBB
UniProt_ID P0CG47
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name RanBP2-NZF-L13T-V14F
Peptide_Sequence KEGQWDCSACTFQNEGSSTKCAACQNPRK
Peptide_Length 29
Peptide_SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3178.49
Aliphatic_Index 10.34483
Aromaticity 0.06897
Average_Rotatable_Bonds 3.65517
Charge_at_pH_7 0.75319
Isoelectric_Point 7.91495
Number_of_Hydrogen_Bond_Acceptors 51
Number_of_Hydrogen_Bond_Donors 53
Topological_Polar_Surface_Area 1453.58000
X_logP_energy -22.37233
Interaction Information
Affinity KD=976 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 1Q5W
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch.
Release_Year 2004
PMID 14976553
DOI 10.1038/sj.emboj.7600115