PPIRE02365

Target Protein Information
Protein_Name Histone chaperone ASF1A
Protein_Sequence MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALPSASKGWSTSENSLNVMLESHMDCM
Organism_Source Homo sapiens
Functional_Classification Epigenetic regulator
Cellular_Localization Nucleus
Gene_Names ASF1A
UniProt_ID Q9Y294
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HIRA453-467
Peptide_Sequence RTADGRRRITPLCIA
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1699.01
Aliphatic_Index 91.33333
Aromaticity 0.00000
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 2.93644
Isoelectric_Point 12.02327
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 787.29000
X_logP_energy -9.27962
Interaction Information
Affinity KD=1.314 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2I32
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly.
Release_Year 2006
PMID 16980972
DOI 10.1038/nsmb1147