PPIRE02450

Target Protein Information
Protein_Name H-2 class I histocompatibility antigen, K-Q alpha chain
Protein_Sequence PRFISVGYVDDTELVRFDSDAENPRYEPRARWMEQVEPEYWERNTQIAKDNEQSSRVDLRTLLRYYNQSAGGSHTIQRMYGCDVGSDGRLLRGYEQVAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGAAERRRAYLEGACVEWLSRHLKNGNATLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPKPLTLRWEPPPSAVSNTVIIAVLVVLGAAIVTGAVVAFVMMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA
Organism_Source Mus musculus
Functional_Classification Immune-related protein
Cellular_Localization Plasma membrane
Gene_Names H2-K1
UniProt_ID P14428
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pBM1
Peptide_Sequence INFDFNTI
Peptide_Length 8
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)[C@@H](C)CC)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 983.09
Aliphatic_Index 97.50000
Aromaticity 0.25000
Average_Rotatable_Bonds 3.75000
Charge_at_pH_7 -1.00157
Isoelectric_Point 3.74999
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 410.73000
X_logP_energy -3.02420
Interaction Information
Affinity KD=2.6 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 1FO0
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Crystal structure of a T cell receptor bound to an allogeneic MHC molecule.
Release_Year 2000
PMID 11017099
DOI 10.1038/79728