PPIRE02521

Target Protein Information
Protein_Name Placenta growth factor
Protein_Sequence MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR
Organism_Source Homo sapiens
Functional_Classification other
Cellular_Localization Extracellular
Gene_Names PGF
UniProt_ID P49763
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 3
Peptide_Sequence WQICDILTLPHCIFN
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method C4<->C12;side chain cyclization;disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1816.17
Aliphatic_Index 130.00000
Aromaticity 0.13333
Average_Rotatable_Bonds 3.60000
Charge_at_pH_7 -1.03461
Isoelectric_Point 5.28752
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 650.11000
X_logP_energy -2.28930
Interaction Information
Affinity IC50=100 uM
Affinity_Assay ELISA
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery.
Release_Year 2011
PMID 21280651
DOI 10.1021/jm101226k