PPIRE02525
Target Protein Information
| Protein_Name | Placenta growth factor |
|---|---|
| Protein_Sequence | MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR |
| Organism_Source | Homo sapiens |
| Functional_Classification | other |
| Cellular_Localization | Extracellular |
| Gene_Names | PGF |
| UniProt_ID | P49763 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | 7 |
|---|---|
| Peptide_Sequence | FDVCNWVGLPHCRVM |
| Peptide_Length | 15 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(C)C)C(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | C4<->C12;side chain cyclization;disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1776.12 |
|---|---|
| Aliphatic_Index | 84.00000 |
| Aromaticity | 0.13333 |
| Average_Rotatable_Bonds | 3.46667 |
| Charge_at_pH_7 | -0.03461 |
| Isoelectric_Point | 7.25386 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 23 |
| Number_of_Hydrogen_Bond_Donors | 24 |
| Topological_Polar_Surface_Area | 648.69000 |
| X_logP_energy | -3.50423 |
Interaction Information
| Affinity | IC50=9 uM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery. |
| Release_Year | 2011 |
| PMID | 21280651 |
| DOI | 10.1021/jm101226k |