PPIRE02529

Target Protein Information
Protein_Name Placenta growth factor
Protein_Sequence MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR
Organism_Source Homo sapiens
Functional_Classification other
Cellular_Localization Extracellular
Gene_Names PGF
UniProt_ID P49763
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 11
Peptide_Sequence LDVCLLAPHCCLAV
Peptide_Length 14
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method C4<->C12;side chain cyclization;disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1469.84
Aliphatic_Index 167.14286
Aromaticity 0.00000
Average_Rotatable_Bonds 3.07143
Charge_at_pH_7 -1.09658
Isoelectric_Point 5.28520
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 498.81000
X_logP_energy -2.02700
Interaction Information
Affinity IC50=5 uM
Affinity_Assay ELISA
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery.
Release_Year 2011
PMID 21280651
DOI 10.1021/jm101226k