PPIRE02532

Target Protein Information
Protein_Name Placenta growth factor
Protein_Sequence MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR
Organism_Source Homo sapiens
Functional_Classification other
Cellular_Localization Extracellular
Gene_Names PGF
UniProt_ID P49763
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 14
Peptide_Sequence AAFAAVVVVQQ
Peptide_Length 11
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method C4<->C12;side chain cyclization;disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1102.30
Aliphatic_Index 141.81818
Aromaticity 0.09091
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 440.50000
X_logP_energy -3.27640
Interaction Information
Affinity IC50=5 uM
Affinity_Assay ELISA
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery.
Release_Year 2011
PMID 21280651
DOI 10.1021/jm101226k