PPIRE02689
Target Protein Information
| Protein_Name | SaV-like |
|---|---|
| Protein_Sequence | MEDMVDHPPHYNQAGVECIDAIEAALGAENFEFYLQGNVMKYLWRYRYKNGVEDLQKAKWYLEKLIDSTYSP |
| Organism_Source | uncultured virus |
| Functional_Classification | other |
| Cellular_Localization | Extracellular |
| Gene_Names | None |
| UniProt_ID | A0A0A0UXU9 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | cyclo-Ac-[CHPQGPPC]-NH2 |
|---|---|
| Peptide_Sequence | CHPQGPPC |
| Peptide_Length | 8 |
| Peptide_SMILES | NC(=O)CC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)CS)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | C1<->C8;side chain cyclization;disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 837.97 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.37500 |
| Charge_at_pH_7 | -0.03506 |
| Isoelectric_Point | 7.25316 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 10 |
| Topological_Polar_Surface_Area | 312.42000 |
| X_logP_energy | -3.96720 |
Interaction Information
| Affinity | KD=670 nM |
|---|---|
| Affinity_Assay | Surface plasmon resonance |
| PDB_ID | 1SLE |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB)does not necessarily enhance affinity or biological activity |
| Release_Year | 1995 |
| PMID | 23151250 |
| DOI | 10.1021/bi9503561 |