PPIRE02752

Target Protein Information
Protein_Name Gastrin-releasing peptide receptor
Protein_Sequence MDPNNCSHLNLEVDPFLSCNNTFNQTLNPPKMDNWFHPGIIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYIIPLSIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFITSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPSLLNRSHSTGRSTTCMTSFKSTNPSATFSLINGNICHEGYV
Organism_Source Rattus norvegicus
Functional_Classification Receptor
Cellular_Localization Plasma membrane
Gene_Names Grpr
UniProt_ID P52500
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name [Tyr4]bombesin
Peptide_Sequence XQRYGNWATGHLM
Peptide_Length 13
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)CN)[C@@H](C)O)C(=O)O
Chemical_Modification X1=pyroglutamate
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Other
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1490.66
Aliphatic_Index 37.69231
Aromaticity 0.15385
Average_Rotatable_Bonds 3.53846
Charge_at_pH_7 1.08804
Isoelectric_Point 9.35118
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 645.53000
X_logP_energy -6.64773
Interaction Information
Affinity KD=1.1 nM
Affinity_Assay Radioreceptor assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Solubilization of the receptor for the neuropeptide gastrin-releasing peptide (bombesin)with functional ligand binding properties.
Release_Year 1990
PMID 2165804
DOI 10.1021/bi00473a022