PPIRE02797

Target Protein Information
Protein_Name GTP-binding protein Rheb
Protein_Sequence MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM
Organism_Source Homo sapiens
Functional_Classification E3 ubiquitin ligase adaptors
Cellular_Localization Lysosome
Gene_Names RHEB
UniProt_ID Q15382
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P1_WT
Peptide_Sequence ATRIGRFANYLRN
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1551.77
Aliphatic_Index 75.38462
Aromaticity 0.15385
Average_Rotatable_Bonds 3.84615
Charge_at_pH_7 2.99712
Isoelectric_Point 12.20421
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 724.86000
X_logP_energy -7.90829
Interaction Information
Affinity KD=0.14 uM
Affinity_Assay Bio-Layer Interferometry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Development of an RHEB-Targeting Peptide To Inhibit mTORC1 Kinase Activity.
Release_Year 2022
PMID 35847293
DOI 10.1021/acsomega.2c01865