PPIRE02826

Target Protein Information
Protein_Name Macrophage scavenger receptor types I and II
Protein_Sequence MTKEMTENQRLCPHEQEDADCSSESVKFDARSMTASLPHSTKNGPSLQEKLKSFKAALIALYLLVFAVLIPVVGIVTAQLLNWEMKNCLVCSLNTSDTSQGPMEKENTSKVEMRFTIIMEHMKDMEERIESISNSKADLIDTERFQNFSMATDQRLNDILLQLNSLISSVQEHGNSLDAISKSLQSLNMTLLDVQLHTETLNVRVRESTAKQQEDISKLEERVYKVSAEVQSVKEEQAHVEQEVKQEVRVLNNITNDLRLKDWEHSQTLKNITFIQGPPGPQGEKGDRGLTGQTGPPGAPGIRGIPGVKGDRGQIGFPGGRGNPGAPGKPGRSGSPGPKGQKGEKGSVGGSTPLKTVRLVGGSGAHEGRVEIFHQGQWGTICDDRWDIRAGQVVCRSLGYQEVLAVHKRAHFGQGTGPIWLNEVMCFGRESSIENCKINQWGVLSCSHSEDAGVTCTS
Organism_Source Mus musculus
Functional_Classification receptor
Cellular_Localization Plasma membrane
Gene_Names Msr1
UniProt_ID P30204
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PEG30kDa-Cys-Tyr-Lys15
Peptide_Sequence CYKKKKKKKKKKKKKKK
Peptide_Length 17
Peptide_SMILES NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CS)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2206.94
Aliphatic_Index 0.00000
Aromaticity 0.05882
Average_Rotatable_Bonds 5.64706
Charge_at_pH_7 14.93073
Isoelectric_Point 11.41105
Number_of_Hydrogen_Bond_Acceptors 35
Number_of_Hydrogen_Bond_Donors 35
Topological_Polar_Surface_Area 939.45000
X_logP_energy -6.03180
Interaction Information
Affinity IC50=390 uM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title PEG-Peptide Inhibition of Scavenger Receptor Uptake of Nanoparticles by the Liver.
Release_Year 2018
PMID 30052459
DOI 10.1021/acs.molpharmaceut.8b00355