PPIRE02829

Target Protein Information
Protein_Name Macrophage scavenger receptor types I and II
Protein_Sequence MTKEMTENQRLCPHEQEDADCSSESVKFDARSMTASLPHSTKNGPSLQEKLKSFKAALIALYLLVFAVLIPVVGIVTAQLLNWEMKNCLVCSLNTSDTSQGPMEKENTSKVEMRFTIIMEHMKDMEERIESISNSKADLIDTERFQNFSMATDQRLNDILLQLNSLISSVQEHGNSLDAISKSLQSLNMTLLDVQLHTETLNVRVRESTAKQQEDISKLEERVYKVSAEVQSVKEEQAHVEQEVKQEVRVLNNITNDLRLKDWEHSQTLKNITFIQGPPGPQGEKGDRGLTGQTGPPGAPGIRGIPGVKGDRGQIGFPGGRGNPGAPGKPGRSGSPGPKGQKGEKGSVGGSTPLKTVRLVGGSGAHEGRVEIFHQGQWGTICDDRWDIRAGQVVCRSLGYQEVLAVHKRAHFGQGTGPIWLNEVMCFGRESSIENCKINQWGVLSCSHSEDAGVTCTS
Organism_Source Mus musculus
Functional_Classification receptor
Cellular_Localization Plasma membrane
Gene_Names Msr1
UniProt_ID P30204
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Tyr-(Acr-Lys4)3-Acr-Lys-Cys-PEG5kDa
Peptide_Sequence YXKKKKXKKKKXKKKKXKC
Peptide_Length 19
Peptide_SMILES NCCCC[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2178.80
Aliphatic_Index 0.00000
Aromaticity 0.05263
Average_Rotatable_Bonds 4.84211
Charge_at_pH_7 12.93132
Isoelectric_Point 11.33395
Number_of_Hydrogen_Bond_Acceptors 35
Number_of_Hydrogen_Bond_Donors 35
Topological_Polar_Surface_Area 945.61000
X_logP_energy -8.79460
Interaction Information
Affinity IC50=5 uM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title PEG-Peptide Inhibition of Scavenger Receptor Uptake of Nanoparticles by the Liver.
Release_Year 2018
PMID 30052459
DOI 10.1021/acs.molpharmaceut.8b00355