PPIRE02830

Target Protein Information
Protein_Name Macrophage scavenger receptor types I and II
Protein_Sequence MTKEMTENQRLCPHEQEDADCSSESVKFDARSMTASLPHSTKNGPSLQEKLKSFKAALIALYLLVFAVLIPVVGIVTAQLLNWEMKNCLVCSLNTSDTSQGPMEKENTSKVEMRFTIIMEHMKDMEERIESISNSKADLIDTERFQNFSMATDQRLNDILLQLNSLISSVQEHGNSLDAISKSLQSLNMTLLDVQLHTETLNVRVRESTAKQQEDISKLEERVYKVSAEVQSVKEEQAHVEQEVKQEVRVLNNITNDLRLKDWEHSQTLKNITFIQGPPGPQGEKGDRGLTGQTGPPGAPGIRGIPGVKGDRGQIGFPGGRGNPGAPGKPGRSGSPGPKGQKGEKGSVGGSTPLKTVRLVGGSGAHEGRVEIFHQGQWGTICDDRWDIRAGQVVCRSLGYQEVLAVHKRAHFGQGTGPIWLNEVMCFGRESSIENCKINQWGVLSCSHSEDAGVTCTS
Organism_Source Mus musculus
Functional_Classification receptor
Cellular_Localization Plasma membrane
Gene_Names Msr1
UniProt_ID P30204
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Lys-(Tyr-Lys4)3-Tyr-Lys-Cys-PEG5kDa
Peptide_Sequence KYKKKKYKKKKYKKKKYKC
Peptide_Length 19
Peptide_SMILES NCCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2568.30
Aliphatic_Index 0.00000
Aromaticity 0.21053
Average_Rotatable_Bonds 5.36842
Charge_at_pH_7 13.92848
Isoelectric_Point 10.98497
Number_of_Hydrogen_Bond_Acceptors 39
Number_of_Hydrogen_Bond_Donors 39
Topological_Polar_Surface_Area 1032.32000
X_logP_energy -4.34630
Interaction Information
Affinity IC50=40 uM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title PEG-Peptide Inhibition of Scavenger Receptor Uptake of Nanoparticles by the Liver.
Release_Year 2018
PMID 30052459
DOI 10.1021/acs.molpharmaceut.8b00355