PPIRE02911

Target Protein Information
Protein_Name Proliferating cell nuclear antigen
Protein_Sequence MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS
Organism_Source Homo sapiens
Functional_Classification other
Cellular_Localization Nucleus
Gene_Names PCNA
UniProt_ID P12004
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name p21Tyr151Phe
Peptide_Sequence GRKRRQTSMTDFFHSKRRLIFS
Peptide_Length 22
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2755.20
Aliphatic_Index 35.45455
Aromaticity 0.13636
Average_Rotatable_Bonds 4.36364
Charge_at_pH_7 6.08873
Isoelectric_Point 12.68544
Number_of_Hydrogen_Bond_Acceptors 39
Number_of_Hydrogen_Bond_Donors 48
Topological_Polar_Surface_Area 1246.18000
X_logP_energy -14.19725
Interaction Information
Affinity KD=250 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4RJF
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title p21 Exploits Residue Tyr151 as a Tether for High-Affinity PCNA Binding.
Release_Year 2015
PMID 25972089
DOI 10.1021/acs.biochem.5b00241