PPIRE02990

Target Protein Information
Protein_Name H-2 class I histocompatibility antigen, K-Q alpha chain
Protein_Sequence PRFISVGYVDDTELVRFDSDAENPRYEPRARWMEQVEPEYWERNTQIAKDNEQSSRVDLRTLLRYYNQSAGGSHTIQRMYGCDVGSDGRLLRGYEQVAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGAAERRRAYLEGACVEWLSRHLKNGNATLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPKPLTLRWEPPPSAVSNTVIIAVLVVLGAAIVTGAVVAFVMMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA
Organism_Source Mus musculus
Functional_Classification Immune-related protein
Cellular_Localization Plasma membrane
Gene_Names H2-K1
UniProt_ID P14428
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SEV9
Peptide_Sequence FAPGNYPAL
Peptide_Length 9
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 949.07
Aliphatic_Index 65.55556
Aromaticity 0.22222
Average_Rotatable_Bonds 2.55556
Charge_at_pH_7 -0.00287
Isoelectric_Point 6.09320
Number_of_Hydrogen_Bond_Acceptors 12
Number_of_Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 341.86000
X_logP_energy -1.92720
Interaction Information
Affinity KD=2 nM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The crystal structures of K(bm1)and K(bm8)reveal that subtle changes in the peptide environment impact thermostability and alloreactivity.
Release_Year 2001
PMID 11290333
DOI 10.1016/s1074-7613(01)00105-4