PPIRE03073

Target Protein Information
Protein_Name Calcium/calmodulin-dependent protein kinase type II subunit alpha
Protein_Sequence MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
Organism_Source Rattus norvegicus
Functional_Classification Enzyme
Cellular_Localization Cytoplasm
Gene_Names Camk2a
UniProt_ID P11275
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name A3K/V10F-AIP
Peptide_Sequence KKKLRRQEAFDAY
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1652.92
Aliphatic_Index 45.38462
Aromaticity 0.15385
Average_Rotatable_Bonds 4.53846
Charge_at_pH_7 2.99846
Isoelectric_Point 10.63018
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 752.30000
X_logP_energy -5.98866
Interaction Information
Affinity IC50=4.1 nM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Critical amino acid residues of AIP, a highly specific inhibitory peptide of calmodulin-dependent protein kinase II.
Release_Year 1998
PMID 9613610
DOI 10.1016/S0014-5793(98)00405-0