PPIRE03090

Target Protein Information
Protein_Name Structural polyprotein
Protein_Sequence SVTEHFNVYKATRPYXXXCADCGDGYFCYSPVAIEKIRDEASDGMLKIQVSAQIGLDKAGTHAHTKLRYMAGHDVQESKRDSLRVYTSAACSIHGTMGHFIVAHCPPGDYLKVSFEDADSHVKACKVQYKHNPLPVGREKFVVRPHFGVELPCTSYQLTTAPTDEEIDMHTPPDIPDRTLLSQTAGNVKITAGGRTIRYNCTWGRDNVGTTSTDKTINACKIDQCHAAVTSHDKWQFTSPFVPRADQTARKGKVHVPFPLTNVTCRVPLARAPDVTYGKKEVTLRLHPDHPTLFSYRSLGAEPHPYEEWVDKFSERIIPVTEEGXEYQWGNNPPVRLWAXLTTEGKPHGWPHEIIQYYYGLYPAATIAAVSGXSLMALLTLAATCCMLATARRKCLTPYALTPGAVVPLTLGLXXCAPRANA
Organism_Source Ross river virus (strain 213970)
Functional_Classification Viral envelope proteins
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P17517
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AB-496
Peptide_Sequence IVPAKSVCGPVYCFTPSPVV
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Other
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2063.50
Aliphatic_Index 97.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 2.75000
Charge_at_pH_7 0.87289
Isoelectric_Point 8.22117
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 688.00000
X_logP_energy -4.84330
Interaction Information
Affinity IC50=239.37 nM
Affinity_Assay Neutralization assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title New neutralizing antibody epitopes in hepatitis C virus envelope glycoproteins are revealed by dissecting peptide recognition profiles.
Release_Year 2011
PMID 22041300
DOI 10.1016/j.vaccine.2011.10.045