PPIRE03113

Target Protein Information
Protein_Name Pol polyprotein
Protein_Sequence AGLLAGSWIPDWTFVSVPPLVTLWYTLTKEPIPGEDVYYVDGACNRNSREGKAGYITQQGKQRVEKLENTTNQQAELTAIKMALEDSGPRVNIVTDSQYA
Organism_Source Simian immunodeficiency virus agm.vervet (isolate AGM266)
Functional_Classification Viral envelope proteins
Cellular_Localization Cytoplasm
Gene_Names pol
UniProt_ID P12500
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Cordymin
Peptide_Sequence AMAPPYGYRTPDAAQ
Peptide_Length 15
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1608.79
Aliphatic_Index 26.66667
Aromaticity 0.13333
Average_Rotatable_Bonds 2.86667
Charge_at_pH_7 -0.00327
Isoelectric_Point 6.32528
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 647.33000
X_logP_energy -6.55093
Interaction Information
Affinity IC50=55 uM
Affinity_Assay ELISA
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Cordymin, an antifungal peptide from the medicinal fungus Cordyceps militaris.
Release_Year 2011
PMID 20739167
DOI 10.1016/j.phymed.2010.07.010