PPIRE03115
Target Protein Information
| Protein_Name | Pol polyprotein |
|---|---|
| Protein_Sequence | AGLLAGSWIPDWTFVSVPPLVTLWYTLTKEPIPGEDVYYVDGACNRNSREGKAGYITQQGKQRVEKLENTTNQQAELTAIKMALEDSGPRVNIVTDSQYA |
| Organism_Source | Simian immunodeficiency virus agm.vervet (isolate AGM266) |
| Functional_Classification | Enzyme |
| Cellular_Localization | Cytoplasm |
| Gene_Names | pol |
| UniProt_ID | P12500 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | coconut antifungal peptide |
|---|---|
| Peptide_Sequence | EQCREEEDDR |
| Peptide_Length | 10 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(=O)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1308.30 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.70000 |
| Charge_at_pH_7 | -4.05600 |
| Isoelectric_Point | 3.84411 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 21 |
| Number_of_Hydrogen_Bond_Donors | 25 |
| Topological_Polar_Surface_Area | 715.91000 |
| X_logP_energy | -9.10806 |
Interaction Information
| Affinity | IC50=52.5 uM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | An antifungal peptide from the coconut. |
| Release_Year | 2005 |
| PMID | 16308082 |
| DOI | 10.1016/j.peptides.2005.05.009 |