PPIRE03116

Target Protein Information
Protein_Name Secreted frizzled-related protein 1
Protein_Sequence MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK
Organism_Source Homo sapiens
Functional_Classification E3 ubiquitin ligase adaptors
Cellular_Localization Extracellular
Gene_Names SFRP1
UniProt_ID Q8N474
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AC2
Peptide_Sequence QGTLVDGRWLVQ
Peptide_Length 12
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1371.56
Aliphatic_Index 113.33333
Aromaticity 0.08333
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 -0.00157
Isoelectric_Point 6.33872
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 604.82000
X_logP_energy -5.22813
Interaction Information
Affinity KD=3.9 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Identification of a peptide binding motif for secreted frizzled-related protein-1.
Release_Year 2004
PMID 15501513
DOI 10.1016/j.peptides.2004.07.010