PPIRE03119
Target Protein Information
| Protein_Name | Pol polyprotein |
|---|---|
| Protein_Sequence | AGLLAGSWIPDWTFVSVPPLVTLWYTLTKEPIPGEDVYYVDGACNRNSREGKAGYITQQGKQRVEKLENTTNQQAELTAIKMALEDSGPRVNIVTDSQYA |
| Organism_Source | Simian immunodeficiency virus agm.vervet (isolate AGM266) |
| Functional_Classification | Viral envelope proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | pol |
| UniProt_ID | P12500 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | (cid:2)-basrubrin |
|---|---|
| Peptide_Sequence | KIMAKPSKFYEQLRGR |
| Peptide_Length | 16 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1952.35 |
|---|---|
| Aliphatic_Index | 55.00000 |
| Aromaticity | 0.12500 |
| Average_Rotatable_Bonds | 4.25000 |
| Charge_at_pH_7 | 3.99802 |
| Isoelectric_Point | 11.11005 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 27 |
| Number_of_Hydrogen_Bond_Donors | 29 |
| Topological_Polar_Surface_Area | 813.74000 |
| X_logP_energy | -6.09976 |
Interaction Information
| Affinity | IC50=370 nM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Antifungal peptides, a heat shock protein-like peptide, and a serine-threonine kinase-like protein from Ceylon spinach seeds. |
| Release_Year | 2004 |
| PMID | 15245882 |
| DOI | 10.1016/j.peptides.2004.05.004 |