PPIRE03122

Target Protein Information
Protein_Name Polycomb protein EED
Protein_Sequence MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
Organism_Source Homo sapiens
Functional_Classification Epigenetic regulator
Cellular_Localization Nucleus
Gene_Names EED
UniProt_ID O75530
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Jarid2-K116me3
Peptide_Sequence XFAQSQPNSPSTTPVK
Peptide_Length 16
Peptide_SMILES CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification X1=N-trimethyllysine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1645.79
Aliphatic_Index 24.37500
Aromaticity 0.06250
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 0.99769
Isoelectric_Point 9.70000
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 729.89000
X_logP_energy -11.98720
Interaction Information
Affinity KD=3 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4X3E
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.
Release_Year 2015
PMID 25620564
DOI 10.1016/j.molcel.2014.12.020