PPIRE03146

Target Protein Information
Protein_Name Protein Mdm4
Protein_Sequence MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
Organism_Source Homo sapiens
Functional_Classification E3 ubiquitin ligase adaptors
Cellular_Localization Nucleus
Gene_Names MDM4
UniProt_ID O15151
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name p53_17-26
Peptide_Sequence ETFSDLWKLL
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1251.44
Aliphatic_Index 117.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 -1.00009
Isoelectric_Point 4.18441
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 482.09000
X_logP_energy -1.29190
Interaction Information
Affinity KD=0.09 uM
Affinity_Assay Bio-Layer Interferometry
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structure of human MDM4 N-terminal domain bound to a single-domain antibody.
Release_Year 2009
PMID 19084022
DOI 10.1016/j.jmb.2008.11.043