PPIRE03161

Target Protein Information
Protein_Name Protein Tat
Protein_Sequence MADRRIPGTAEENLQKSSGGVPGQNTGGQEARPNYHCQLCFLRSLGIDYLDASLRKKNKQRLKAIQQGRQPQYLL
Organism_Source Equine infectious anemia virus (strain Wyoming)
Functional_Classification Viral envelope proteins
Cellular_Localization Nucleus
Gene_Names tat
UniProt_ID P20920
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Fluorescein-rhodamine-labeled Tat peptide
Peptide_Sequence AAARKKRRQRRRAAAC
Peptide_Length 16
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Other
C-terminal_Modification other
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1869.23
Aliphatic_Index 37.50000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.18750
Charge_at_pH_7 7.93540
Isoelectric_Point 12.80742
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 39
Topological_Polar_Surface_Area 966.35000
X_logP_energy -13.17738
Interaction Information
Affinity KD=100 nM
Affinity_Assay Laser induced liquid bead ion desorption
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Binding sites of the viral RNA element TAR and of TAR mutants for various peptide ligands, probed with LILBID: a new laser mass spectrometry.
Release_Year 2008
PMID 18693035
DOI 10.1016/j.jasms.2008.07.001