PPIRE03168

Target Protein Information
Protein_Name HLA class I histocompatibility antigen, B alpha chain
Protein_Sequence MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSLTA
Organism_Source Homo sapiens
Functional_Classification Immune-related protein
Cellular_Localization Plasma membrane
Gene_Names HLA-B
UniProt_ID P01889
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name KK10
Peptide_Sequence KRWIILGLNK
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1240.56
Aliphatic_Index 156.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 4.30000
Charge_at_pH_7 2.99739
Isoelectric_Point 11.82306
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 498.04000
X_logP_energy -1.30203
Interaction Information
Affinity KD=1.5 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 4G8G
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells.
Release_Year 2013
PMID 23521884
DOI 10.1016/j.immuni.2012.11.021