PPIRE03239

Target Protein Information
Protein_Name Envelope glycoprotein
Protein_Sequence MACSTLPKSPKDKIDPRDLLIPLILFLSLKGARSAAPGSSPHQVYNITWEVTNGDRETVWAISGRLYVSGRDPGLTFGIRLRYQNLGPRVPIGPNPVLAD
Organism_Source Myeloproliferative leukemia virus
Functional_Classification Viral envelope proteins
Cellular_Localization Plasma membrane
Gene_Names env
UniProt_ID P40932
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FPPR-N36
Peptide_Sequence TLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL
Peptide_Length 46
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 5247.18
Aliphatic_Index 146.30435
Aromaticity 0.02174
Average_Rotatable_Bonds 3.97826
Charge_at_pH_7 3.09036
Isoelectric_Point 12.22264
Number_of_Hydrogen_Bond_Acceptors 69
Number_of_Hydrogen_Bond_Donors 76
Topological_Polar_Surface_Area 2264.31000
X_logP_energy -20.81599
Interaction Information
Affinity IC50=1.51 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Heptad repeat 1-derived N peptide inhibitors improve broad-spectrum anti-HIV-1 activity.
Release_Year 2025
PMID 40093556
DOI 10.1016/j.crmicr.2025.100364