PPIRE03291

Target Protein Information
Protein_Name RAC-alpha serine/threonine-protein kinase
Protein_Sequence MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Organism_Source Homo sapiens
Functional_Classification Enzyme
Cellular_Localization Cytoplasm
Gene_Names AKT1
UniProt_ID P31749
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ATP-GSK3 bisubstrate peptide
Peptide_Sequence RSGRARTSSFAEPGGK
Peptide_Length 16
Peptide_SMILES C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Other
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1663.81
Aliphatic_Index 12.50000
Aromaticity 0.06250
Average_Rotatable_Bonds 3.43750
Charge_at_pH_7 2.99945
Isoelectric_Point 12.22264
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 820.97000
X_logP_energy -13.50549
Interaction Information
Affinity Ki=3.6 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID 6BUU
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.
Release_Year 2018
PMID 30078705
DOI 10.1016/j.cell.2018.07.003