PPIRE03311

Target Protein Information
Protein_Name Proto-oncogene tyrosine-protein kinase Src
Protein_Sequence MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Organism_Source Homo sapiens
Functional_Classification Enzyme
Cellular_Localization Cytoplasm
Gene_Names SRC
UniProt_ID P12931
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name C[RE]4
Peptide_Sequence RERERERE
Peptide_Length 8
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method N1<->C10, main chain cyclization, amide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1159.23
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 5.37500
Charge_at_pH_7 0.00507
Isoelectric_Point 6.66942
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 663.82000
X_logP_energy -7.69582
Interaction Information
Affinity IC50=52.6 uM
Affinity_Assay Bio-Layer Interferometry
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Cyclic peptides containing tryptophan and arginine as Src kinase inhibitors.
Release_Year 2013
PMID 23602444
DOI 10.1016/j.bmcl.2013.03.124