PPIRE03317

Target Protein Information
Protein_Name von Hippel-Lindau disease tumor suppressor
Protein_Sequence MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
Organism_Source Homo sapiens
Functional_Classification other
Cellular_Localization Cytoplasm
Gene_Names VHL
UniProt_ID P40337
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name B-CODD
Peptide_Sequence DLDLEALAXYIPADDDFQLR
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification X9=4-hydroxyproline
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Other
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2250.45
Aliphatic_Index 112.50000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.60000
Charge_at_pH_7 -4.99886
Isoelectric_Point 3.47933
Number_of_Hydrogen_Bond_Acceptors 30
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 956.45000
X_logP_energy -7.00463
Interaction Information
Affinity IC50=226 nM
Affinity_Assay Bio-Layer Interferometry
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title A multivalent peptide as an activator of hypoxia inducible factor-1Alpha.
Release_Year 2013
PMID 23416007
DOI 10.1016/j.bmcl.2013.01.058