PPIRE03351

Target Protein Information
Protein_Name Interferon beta
Protein_Sequence MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN
Organism_Source Homo sapiens
Functional_Classification Immune-related protein
Cellular_Localization Extracellular
Gene_Names IFNB1
UniProt_ID P01574
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AS-2
Peptide_Sequence IAASLEESKEVVAH
Peptide_Length 14
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1482.65
Aliphatic_Index 118.57143
Aromaticity 0.00000
Average_Rotatable_Bonds 3.57143
Charge_at_pH_7 -1.90608
Isoelectric_Point 4.47387
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 648.68000
X_logP_energy -6.16160
Interaction Information
Affinity KD=12.2 uM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Quartz crystal microbalance biosensor for recombinant human interferon-beta detection based on antisense peptide approach.
Release_Year 2007
PMID 17416227
DOI 10.1016/j.aca.2007.03.022