PPIRE03376

Target Protein Information
Protein_Name Gastrin-releasing peptide receptor
Protein_Sequence MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV
Organism_Source Homo sapiens
Functional_Classification Receptor
Cellular_Localization Plasma membrane
Gene_Names GRPR
UniProt_ID P30550
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name [Tyr4]bombesin
Peptide_Sequence XQRYGNQWAVGHLM
Peptide_Length 14
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)CN)C(C)C)C(=O)O
Chemical_Modification X1=pyroglutamate
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Other
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1616.82
Aliphatic_Index 55.71429
Aromaticity 0.14286
Average_Rotatable_Bonds 3.64286
Charge_at_pH_7 1.08804
Isoelectric_Point 9.35118
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 697.49000
X_logP_energy -6.62223
Interaction Information
Affinity KD=0.41 uM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Characterization of bombesin/gastrin-releasing peptide receptors in membranes of MKN45 human gastric cancer.
Release_Year 1994
PMID 7923093
DOI 10.1016/0304-3835(94)90246-1