PPIRE03462

Target Protein Information
Protein_Name Gastrin-releasing peptide receptor
Protein_Sequence MDPNNCSHLNLEVDPFLSCNNTFNQTLNPPKMDNWFHPGIIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYIIPLSIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFITSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPSLLNRSHSTGRSTTCMTSFKSTNPSATFSLINGNICHEGYV
Organism_Source Rattus norvegicus
Functional_Classification receptor
Cellular_Localization Plasma membrane
Gene_Names Grpr
UniProt_ID P52500
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name bombesin-(1-14)
Peptide_Sequence EQRLGNQWAVGHLM
Peptide_Length 14
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(=O)O)C(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Other
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1638.86
Aliphatic_Index 83.57143
Aromaticity 0.07143
Average_Rotatable_Bonds 3.85714
Charge_at_pH_7 0.09067
Isoelectric_Point 7.55131
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 714.56000
X_logP_energy -6.29103
Interaction Information
Affinity IC50=1.54 nM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Structure-activity requirements of bombesin for gastrin-releasing peptide- and neuromedin B-preferring bombesin receptors in rat brain.
Release_Year 1993
PMID 8243536
DOI 10.1016/0014-2999(93)90896-p