PPIRE03470
Target Protein Information
| Protein_Name | Chymotrypsin-like elastase family member 2A |
|---|---|
| Protein_Sequence | MIRTLLLSTLVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANSWVLTAAHCISSSRTYRVGLGRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRLLVVDYATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGGPLNCQASDGRWQVHGIVSFGSRLGCNYYHKPSVFTRVSNYIDWINSVIANN |
| Organism_Source | Homo sapiens |
| Functional_Classification | Enzyme |
| Cellular_Localization | Extracellular |
| Gene_Names | CELA2A |
| UniProt_ID | P08217 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | NH2-Ala-Ala-Pro-Leu-CH2Cl |
|---|---|
| Peptide_Sequence | AAPLX |
| Peptide_Length | 5 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)N)C(=O)NCC(=O)O |
| Chemical_Modification | X5=chloromethyl ketone |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | other |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 427.50 |
|---|---|
| Aliphatic_Index | 118.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.00000 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 6 |
| Number_of_Hydrogen_Bond_Donors | 5 |
| Topological_Polar_Surface_Area | 170.93000 |
| X_logP_energy | -1.43900 |
Interaction Information
| Affinity | Ki=547 uM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Inhibition of human pancreatic elastase 2 by peptide chloromethyl ketones. |
| Release_Year | 1980 |
| PMID | 6901613 |
| DOI | 10.1016/0005-2744(80)90172-2 |