PPIRE03600

Target Protein Information
Protein_Name DNA-binding protein inhibitor ID-1
Protein_Sequence MKVASGSTATAAAGPSCALKAGKTASGAGEVVRCLSEQSVAISRCAGGAGARLPALLDEQQVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVGTPGGRGLPVRAPLSTLNGEISALTAEAACVPADDRILCR
Organism_Source Homo sapiens
Functional_Classification Transcriptional regulator
Cellular_Localization Nucleus
Gene_Names ID1
UniProt_ID P41134
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 3A
Peptide_Sequence KVEILQHVIDYIEGLQALLRDQ
Peptide_Length 22
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2594.01
Aliphatic_Index 155.00000
Aromaticity 0.04545
Average_Rotatable_Bonds 4.09091
Charge_at_pH_7 -1.90781
Isoelectric_Point 4.53867
Number_of_Hydrogen_Bond_Acceptors 34
Number_of_Hydrogen_Bond_Donors 36
Topological_Polar_Surface_Area 1089.72000
X_logP_energy -6.35303
Interaction Information
Affinity IC50=23.9 uM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Affinity of synthetic peptide fragments of MyoD for Id1 protein and their biological effects in several cancer cells.
Release_Year 2010
PMID 20235117
DOI 10.1002/psc.1216