PPIRE03627

Target Protein Information
Protein_Name Genome polyprotein
Protein_Sequence MMTSPSDYQSNSSLATTYSNAPKLSKALSNKYDYLYEVDILKENQKISDTYLPLLNPYSAFAKRSVTPWSQIRSLVQSKPRHVKEYVAASKLDQHPVFATGEEQFVTLHIPEEFASHWKSHQFTHIHFGAVKIALTYHGRKGQPVVARLALLDTRYLEYQHANLGTAEITLNAGTVFITLFPNFTMSLSDANLSTALKIQVQIQGAPLTKDSIQATLHYQIAWRVQNHAMDLTLPGGEEALFLKIDAGNGATQCTQVPRQLSKEDLIKILPDSWVTNYEKLKEPEEPLRSTEVSMSKRHDKSVAISFDHSHYKKLRNTHHFMGMISDDVIVLDDPETFSKTLPSLMQTHDWIHHFQLDGRAVSWYKDPFDGHCPWDIDCQCYSCLYSEDEEDFEDGFPTKYKGIPRPGSIAERKMQEEANLKKLYEDKDPFVGSLSRPGKYEYLVRYDAPSWAKDPHLTVEPTGWDSDEPILPNQPFITRNTLPKIYMFNPLNYENNFPPLSSFSKDGADHTPKIPKRNVVLPSGAKDPTGDLEATVNWQTENALAQNRMLTTIDRTLKETVTKVDRVSDQSSKNQGLIRVLEQQLQDLNKRICPPGTSLFHFFDQQKSEMASLKEQIRLLKEQPQKNETDTPSYQSSYQPFHNFSSPYMPSNPPNSPFTNFANTPQPQPSLFSQYPIQPKSPNTFDLAKLVWEKKDAIAEEKRAKKKLQKDEVKQKTSLPPESKRPDPQSSSHLGDQFMISDPTLPKVYELNEPSVPSEDTSSQSYISTEESVEDTDSFSVVSEESTQLSQLSSSSNDSPENNENTLPQTFMVRPTEPEISEVEDEVDGMTEEPIPERRPEITPPKMVGTGFHTFSLDDISITKWPERIQDFHTWMLTKQLVEREPFLILSEFTARLSGTLREWWNSVGPDDKNRFLTSQDFTWNIRILYSYFCGDQSQNKEELRRQIFEMKCLSYDRKKIDRHFQRMIKLFYHIGGDISLKQAFISSLPPILSERISALIKERGTSGTQMHVGDIRQTGFYVLDDLCSKRKFFNQMKKMSRDLEKACTKSDLIIKGDKGCSGYCNPSRRRKYKRFKLPSFKERDGRQYRKRRRFFRKSKTSKAMRQKPRSCFTCGKIGHFSRNCPQNKKSIKLISEIQKYTGIDIEDDLESVFSIEDEPSEDTLFSLEFYEEYAGEQYQITSYEAPKTENPPLPKIHTIVEIPQTEVKVYTSKWDKPISVIAFYDTGAAYSIMDPAILPSEYWIPHFRHFGTADDGILTTTVKTKHPITIEFFPGFKYTTKLLGSDIPGKDLLIGFDIYRQLNNKLRIGADGIRWKNQFKRYTEIPRLFQLTTSNELQQLEDVIKNQLCAESHVDFLSKCSHPLWLNQDFFIQLPFKRNENINPTKASHSGMNPEHLQLALKECDELQQFDLIEPSDSQWACEAFYVNKRSEQVRGKLRLVINYQPLNHFLQDDKFPIPNKLTLFSHLSKAKLFSKFDLKSGFWQLGIHPNERPKTGFCIPDRHFQWKVMPFGLKTAPSLFQKAMIKIFQPILFSALVYIDDILLFSETLEDHIKLLNQFISLVKKFGVMLSAKKMILAQNKIQFLGMDFADGTFSPAGHISLELQKFPDTNLSVKQIQQFLGIVNYIRDFIPEVTEHISPLSDMLKKKPPAWGKCQDNAVKQLKQLAQQVKSLHIPSEGKKILQTDASDQYWSAVLLEEHNGKRKICGFASGKFKVSEQHYHSTFKEILAVKNGIKKFNFFLIHTNFLVEMDMRAFPKMIRLNPKIVPNSQLLRWAQWFSPYQFEVKHLKGKDNILADFLSRPHEFSQRLKNSPKVLMFQRRTRSNSTKSKADSSQSTGSSYKLSHNLPENPPEAFDLDYPWDTSVFLERRTFYELQVFKKYGGSILRPFGVDPEYPFAHIFIPNPTDFSEDLLWMFWYLLNHFHILMEFRCSKFSKFDQVNPWMMKFLLWFNNHNYWASLFKCMKGIKKYVVIWFYRPVNYYQGKLCALPHSSIVKWNHVSVLNDEDEYSELQRFIFQENKCIPKEIWPGSLGSWNYGNSDHPHGQWIRDALREYREMNDYFQDAQDPYPAYSKVDLTQEELNTLRITRSYGSSSEDADMVKRSIYTVQSNIVKNSPRKRKGKAKSKSSTRNEKRRAKNKCKYRSLHGEDWWIELGYSTKPSTPSWTQDSSSEPCI
Organism_Source Petunia vein clearing virus (isolate Hohn)
Functional_Classification Enzyme
Cellular_Localization Cytoplasm
Gene_Names None
UniProt_ID Q6XKE6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AbF1
Peptide_Sequence PQITLGGGXTLNF
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification X9=alpha-aminobutyric acid
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1274.44
Aliphatic_Index 90.00000
Aromaticity 0.07692
Average_Rotatable_Bonds 3.07692
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 525.17000
X_logP_energy -6.55030
Interaction Information
Affinity IC50=225 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Synthetic interface peptides alter dimeric assembly of the HIV 1 and 2 proteases.
Release_Year 1992
PMID 1338945
DOI 10.1002/pro.5560011003