PPIRE03631

Target Protein Information
Protein_Name Genome polyprotein
Protein_Sequence MMTSPSDYQSNSSLATTYSNAPKLSKALSNKYDYLYEVDILKENQKISDTYLPLLNPYSAFAKRSVTPWSQIRSLVQSKPRHVKEYVAASKLDQHPVFATGEEQFVTLHIPEEFASHWKSHQFTHIHFGAVKIALTYHGRKGQPVVARLALLDTRYLEYQHANLGTAEITLNAGTVFITLFPNFTMSLSDANLSTALKIQVQIQGAPLTKDSIQATLHYQIAWRVQNHAMDLTLPGGEEALFLKIDAGNGATQCTQVPRQLSKEDLIKILPDSWVTNYEKLKEPEEPLRSTEVSMSKRHDKSVAISFDHSHYKKLRNTHHFMGMISDDVIVLDDPETFSKTLPSLMQTHDWIHHFQLDGRAVSWYKDPFDGHCPWDIDCQCYSCLYSEDEEDFEDGFPTKYKGIPRPGSIAERKMQEEANLKKLYEDKDPFVGSLSRPGKYEYLVRYDAPSWAKDPHLTVEPTGWDSDEPILPNQPFITRNTLPKIYMFNPLNYENNFPPLSSFSKDGADHTPKIPKRNVVLPSGAKDPTGDLEATVNWQTENALAQNRMLTTIDRTLKETVTKVDRVSDQSSKNQGLIRVLEQQLQDLNKRICPPGTSLFHFFDQQKSEMASLKEQIRLLKEQPQKNETDTPSYQSSYQPFHNFSSPYMPSNPPNSPFTNFANTPQPQPSLFSQYPIQPKSPNTFDLAKLVWEKKDAIAEEKRAKKKLQKDEVKQKTSLPPESKRPDPQSSSHLGDQFMISDPTLPKVYELNEPSVPSEDTSSQSYISTEESVEDTDSFSVVSEESTQLSQLSSSSNDSPENNENTLPQTFMVRPTEPEISEVEDEVDGMTEEPIPERRPEITPPKMVGTGFHTFSLDDISITKWPERIQDFHTWMLTKQLVEREPFLILSEFTARLSGTLREWWNSVGPDDKNRFLTSQDFTWNIRILYSYFCGDQSQNKEELRRQIFEMKCLSYDRKKIDRHFQRMIKLFYHIGGDISLKQAFISSLPPILSERISALIKERGTSGTQMHVGDIRQTGFYVLDDLCSKRKFFNQMKKMSRDLEKACTKSDLIIKGDKGCSGYCNPSRRRKYKRFKLPSFKERDGRQYRKRRRFFRKSKTSKAMRQKPRSCFTCGKIGHFSRNCPQNKKSIKLISEIQKYTGIDIEDDLESVFSIEDEPSEDTLFSLEFYEEYAGEQYQITSYEAPKTENPPLPKIHTIVEIPQTEVKVYTSKWDKPISVIAFYDTGAAYSIMDPAILPSEYWIPHFRHFGTADDGILTTTVKTKHPITIEFFPGFKYTTKLLGSDIPGKDLLIGFDIYRQLNNKLRIGADGIRWKNQFKRYTEIPRLFQLTTSNELQQLEDVIKNQLCAESHVDFLSKCSHPLWLNQDFFIQLPFKRNENINPTKASHSGMNPEHLQLALKECDELQQFDLIEPSDSQWACEAFYVNKRSEQVRGKLRLVINYQPLNHFLQDDKFPIPNKLTLFSHLSKAKLFSKFDLKSGFWQLGIHPNERPKTGFCIPDRHFQWKVMPFGLKTAPSLFQKAMIKIFQPILFSALVYIDDILLFSETLEDHIKLLNQFISLVKKFGVMLSAKKMILAQNKIQFLGMDFADGTFSPAGHISLELQKFPDTNLSVKQIQQFLGIVNYIRDFIPEVTEHISPLSDMLKKKPPAWGKCQDNAVKQLKQLAQQVKSLHIPSEGKKILQTDASDQYWSAVLLEEHNGKRKICGFASGKFKVSEQHYHSTFKEILAVKNGIKKFNFFLIHTNFLVEMDMRAFPKMIRLNPKIVPNSQLLRWAQWFSPYQFEVKHLKGKDNILADFLSRPHEFSQRLKNSPKVLMFQRRTRSNSTKSKADSSQSTGSSYKLSHNLPENPPEAFDLDYPWDTSVFLERRTFYELQVFKKYGGSILRPFGVDPEYPFAHIFIPNPTDFSEDLLWMFWYLLNHFHILMEFRCSKFSKFDQVNPWMMKFLLWFNNHNYWASLFKCMKGIKKYVVIWFYRPVNYYQGKLCALPHSSIVKWNHVSVLNDEDEYSELQRFIFQENKCIPKEIWPGSLGSWNYGNSDHPHGQWIRDALREYREMNDYFQDAQDPYPAYSKVDLTQEELNTLRITRSYGSSSEDADMVKRSIYTVQSNIVKNSPRKRKGKAKSKSSTRNEKRRAKNKCKYRSLHGEDWWIELGYSTKPSTPSWTQDSSSEPCI
Organism_Source Petunia vein clearing virus (isolate Hohn)
Functional_Classification Enzyme
Cellular_Localization Cytoplasm
Gene_Names None
UniProt_ID Q6XKE6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name IKPL
Peptide_Sequence KPQITL
Peptide_Length 6
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 698.86
Aliphatic_Index 130.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 0.99769
Isoelectric_Point 9.70000
Number_of_Hydrogen_Bond_Acceptors 10
Number_of_Hydrogen_Bond_Donors 9
Topological_Polar_Surface_Area 289.37000
X_logP_energy -1.80400
Interaction Information
Affinity IC50=2000 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Synthetic interface peptides alter dimeric assembly of the HIV 1 and 2 proteases.
Release_Year 1992
PMID 1338945
DOI 10.1002/pro.5560011003