PPIRE03657

Target Protein Information
Protein_Name Vacuolar protein sorting-associated protein 4A
Protein_Sequence MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCVQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQES
Organism_Source Homo sapiens
Functional_Classification other
Cellular_Localization Cytoplasm
Gene_Names VPS4A
UniProt_ID Q9UN37
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name None
Peptide_Sequence SHRPPPPGHRV
Peptide_Length 11
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1236.40
Aliphatic_Index 26.36364
Aromaticity 0.00000
Average_Rotatable_Bonds 2.81818
Charge_at_pH_7 2.17980
Isoelectric_Point 12.50011
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 520.55000
X_logP_energy -5.99106
Interaction Information
Affinity KD=4.6 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 2JQ9
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Development of QSAR-Improved Statistical Potential for the Structure-Based Analysis of Protein?Peptide Binding Affinities.
Release_Year 2013
PMID 27480231
DOI 10.1002/minf.201300064