PPIRE03699

Target Protein Information
Protein_Name 14-3-3 protein sigma
Protein_Sequence MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTADNAGEEGGEAPQEPQS
Organism_Source Homo sapiens
Functional_Classification E3 ubiquitin ligase adaptors
Cellular_Localization Cytoplasm
Gene_Names SFN
UniProt_ID P31947
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CRaf
Peptide_Sequence QHRYXTPHAFTFNTSSPCSEGSLSQRQRSTXTPNVH
Peptide_Length 36
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O)C(C)C)[C@@H](C)O)[C@@H](C)O
Chemical_Modification X5=phosphoserine;X31=phosphoserine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3974.26
Aliphatic_Index 21.66667
Aromaticity 0.08333
Average_Rotatable_Bonds 3.41667
Charge_at_pH_7 2.20965
Isoelectric_Point 9.50246
Number_of_Hydrogen_Bond_Acceptors 62
Number_of_Hydrogen_Bond_Donors 65
Topological_Polar_Surface_Area 1822.70000
X_logP_energy -29.17829
Interaction Information
Affinity KD=1.5 uM
Affinity_Assay Bio-Layer Interferometry
PDB_ID 4FJ3
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Targeting the Surface of the Protein 14-3-3 by Ultrasmall (1.5?nm)Gold Nanoparticles Carrying the Specific Peptide CRaf.
Release_Year 2020
PMID 33275809
DOI 10.1002/cbic.202000761