PPIRE03710

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 2B
Protein_Sequence KTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIKGLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSDGSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGLDLDDICAEAKDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQKISPDYRNMIGQGA
Organism_Source Mus musculus
Functional_Classification Immune-related protein
Cellular_Localization Extracellular
Gene_Names Ighg2b
UniProt_ID P01867
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CEP1
Peptide_Sequence CKIHAXEIFDSXGNPTVECK
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C)[C@@H](C)O)[C@@H](C)CC
Chemical_Modification X6=Citrulline; X12=Citrulline
Cyclization_Method C1<->C20;side chain cyclization;disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2105.37
Aliphatic_Index 58.50000
Aromaticity 0.05000
Average_Rotatable_Bonds 3.45000
Charge_at_pH_7 -1.03165
Isoelectric_Point 5.54436
Number_of_Hydrogen_Bond_Acceptors 32
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 883.60000
X_logP_energy -10.44310
Interaction Information
Affinity KD=3.5 uM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Release_Year 2019
PMID 30152126
DOI 10.1002/art.40698