PPIRE03820
Target Protein Information
| Protein_Name | Dipeptidyl peptidase 1 |
|---|---|
| Protein_Sequence | MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL |
| Organism_Source | Homo sapiens |
| Functional_Classification | cysteine proteases |
| Cellular_Localization | Lysosome |
| Gene_Names | CTSC |
| UniProt_ID | P53634 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Gly-Ile-CN |
|---|---|
| Peptide_Sequence | GI |
| Peptide_Length | 2 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)CN)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | nitrile |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 188.23 |
|---|---|
| Aliphatic_Index | 195.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.50000 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 3 |
| Number_of_Hydrogen_Bond_Donors | 3 |
| Topological_Polar_Surface_Area | 92.42000 |
| X_logP_energy | -0.43940 |
Interaction Information
| Affinity | Ki=110 uM |
|---|---|
| Affinity_Assay | fluorescence assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis. |
| Release_Year | 2012 |
| PMID | 22928782 |
| DOI | 10.1021/bi300719b |