PPIRE03850
Target Protein Information
| Protein_Name | Gag-Pol polyprotein |
|---|---|
| Protein_Sequence | MGARASVLSGGELDRWEKIRLRPGGKKKYKLKHIVWASRELERFAVNPSLLETSEGCRQILGQLQPSLQTGSEELKSLFNTVATLYCVHQRIEVKDTKEALEKIEEEQNKSKKKAQQAAADTGNSSKVSQNYPIVQNIQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPAQAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTSNPPIPVGEIYKRWIILGLNKIVRMYSPSSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTACQGVGGPGHKARVLAEAMSQVTNSTTIMMQRGNFRNQRKIIKCFNCGKEGHLARNCRAPRKKGCWKCGKEGHQMKDCNERQANFLREDLAFLQGKAREFSSEQTRANSPSRGELQVWGRDNNPLSEAGAERQGTVSFSFPQITLWQRPLVTLKIGGQLKEALLDTGADDTVLEEMNSPGRWKP |
| Organism_Source | Human immunodeficiency virus type 1 group M subtype B (isolate JH32) |
| Functional_Classification | proteases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | gag-pol |
| UniProt_ID | P12498 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Cbz-Ile-Phe-H |
|---|---|
| Peptide_Sequence | IF |
| Peptide_Length | 2 |
| Peptide_SMILES | CC[C@H](C)[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Carbobenzoxy |
| C-terminal_Modification | aldehyde |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 278.35 |
|---|---|
| Aliphatic_Index | 195.00000 |
| Aromaticity | 0.50000 |
| Average_Rotatable_Bonds | 3.50000 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 3 |
| Number_of_Hydrogen_Bond_Donors | 3 |
| Topological_Polar_Surface_Area | 92.42000 |
| X_logP_energy | 1.17190 |
Interaction Information
| Affinity | IC50=31 uM |
|---|---|
| Affinity_Assay | solid-phase immunoassay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Effect of pteridine derivatives on intracellular calcium concentration in human monocytic cells. |
| Release_Year | 1993 |
| PMID | 8440379 |
| DOI | 10.1016/0014-5793(93)80522-v |